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Plants absorb sulfate from their environment and assimilate it via a reductive pathway which involves, respectively, a series of transporters and enzymes belonging to multigenic families

This figure depicts the interconnected signaling pathways linking gut-derived peptides and central neuropeptides to hypothalamic and brainstem circuits controlling appetite, satiety, and behavior

Among these systems, glutathione (GSH) peroxidase 4 (GPX4) plays a dominant role by converting LOOH into nontoxic lipid alcohols (LOH) using GSH as an electron donor 10